North America Native Plant

Wild Quinine

Botanical name: Parthenium integrifolium var. integrifolium

USDA symbol: PAINI

Life cycle: perennial

Habit: forb

Native status: Native to the lower 48 states  

Synonyms: Parthenium integrifolium L. var. henryanum Mears (PAINH)   

Wild Quinine: A Prairie Powerhouse for Your Native Garden If you’re looking for a sturdy, low-maintenance native plant that delivers both beauty and ecological benefits, wild quinine (Parthenium integrifolium var. integrifolium) deserves a spot on your must-grow list. This unassuming prairie perennial might not have the flashiest flowers, but what ...

Wild Quinine: A Prairie Powerhouse for Your Native Garden

If you’re looking for a sturdy, low-maintenance native plant that delivers both beauty and ecological benefits, wild quinine (Parthenium integrifolium var. integrifolium) deserves a spot on your must-grow list. This unassuming prairie perennial might not have the flashiest flowers, but what it lacks in drama, it more than makes up for in reliability and wildlife appeal.

What Is Wild Quinine?

Wild quinine is a native North American perennial forb – essentially a non-woody herbaceous plant that comes back year after year. Don’t let the common name fool you; this plant isn’t related to the quinine tree at all. Early settlers simply noticed that Native Americans used it medicinally, much like they used actual quinine for fevers.

You might also see this plant listed under its synonym, Parthenium integrifolium var. henryanum, but they’re the same reliable garden performer either way.

Where Wild Quinine Calls Home

This prairie native has quite an impressive range across the lower 48 states. You’ll find wild populations thriving from the eastern seaboard all the way to the Great Plains, spanning 27 states including Alabama, Arkansas, Connecticut, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, New York, North Carolina, Ohio, Oklahoma, Pennsylvania, South Carolina, Tennessee, Texas, Virginia, West Virginia, and Wisconsin.

Why Gardeners Love Wild Quinine

Wild quinine brings several compelling qualities to your garden:

  • Pollinator magnet: The flat-topped clusters of small white flowers are absolute bee and butterfly magnets during summer bloom time
  • Low maintenance: Once established, this tough perennial basically takes care of itself
  • Drought tolerance: Perfect for gardeners dealing with dry spells or wanting to reduce watering
  • Wildlife benefits: Seeds feed birds, and the plant provides habitat for beneficial insects
  • Interesting texture: The seed heads add winter interest and architectural appeal

Perfect Garden Roles

Wild quinine shines brightest in naturalized settings where it can spread and form colonies. It’s absolutely perfect for:

  • Prairie and meadow gardens
  • Native plant landscapes
  • Pollinator gardens
  • Rain gardens and bioswales
  • Naturalized borders and edges

This isn’t typically a plant for formal flower beds or small container gardens – it prefers room to roam and looks best when planted in drifts or allowed to naturalize.

Growing Conditions and Care

One of wild quinine’s best features is how adaptable it is to different growing conditions:

  • Light: Full sun to partial shade (though it flowers best in full sun)
  • Soil: Well-drained soils of almost any type – clay, loam, or sandy
  • Water: Drought tolerant once established, but appreciates occasional watering during prolonged dry spells
  • Hardiness: Thrives in USDA zones 3-8, making it suitable for most temperate climates

Planting and Care Tips

Getting wild quinine established in your garden is refreshingly straightforward:

  • Planting: Spring or fall planting works well; space plants 18-24 inches apart
  • Establishment: Water regularly the first year to help roots develop
  • Maintenance: Minimal care needed once established – just occasional weeding around young plants
  • Propagation: Can self-seed readily, or you can collect and sow seeds in fall
  • Height and spread: Expect plants to reach 2-4 feet tall and gradually spread to form colonies

A Few Things to Consider

While wild quinine is generally well-behaved, keep these points in mind:

  • It can self-seed and spread, so give it space or be prepared to manage seedlings
  • The flowers, while attractive to pollinators, aren’t particularly showy for human eyes
  • It’s deciduous, so it dies back completely in winter

The Bottom Line

Wild quinine might not win any beauty contests, but it’s exactly the kind of steady, reliable native plant that forms the backbone of successful wildlife gardens. If you have space for a naturalized area and want to support local ecosystems while enjoying a truly low-maintenance perennial, wild quinine delivers on all fronts. Plus, there’s something deeply satisfying about growing a plant that’s been thriving in North American landscapes for thousands of years – long before any of us started fussing over garden design!

Wild Quinine

Classification

Group

Dicot

Kingdom

Plantae - Plants

Subkingdom

Tracheobionta - Vascular plants

Superdivision

Spermatophyta - Seed plants

Division

Magnoliophyta - Flowering plants

Subdivision
Class

Magnoliopsida - Dicotyledons

Subclass

Asteridae

Order

Asterales

Family

Asteraceae Bercht. & J. Presl - Aster family

Genus

Parthenium L. - feverfew

Species

Parthenium integrifolium L. - wild quinine

Plant data source: USDA, NRCS 2025. The PLANTS Database. https://plants.usda.gov,. 2/25/2025. National Plant Data Team, Greensboro, NC USA